Custom Peptides
Cayman Chemical Dexrazoxane 10mg
An intracellular iron chelator and an inhibitor of topoisomerase IIα that is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury; scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), DPPH (IC50 = 3.5 μM), and ABTS+ (IC50 = 3.8 mM) free radicals
Cayman Chemical Nmethyl2AIhydrochLRIde 10mg
An AI that reduces nociception and inhibits exploratory in mice; intended for forensic and research purposes
Cayman Chemical MeOSucAlaAlaProValAMC 10mg
A fluorogenic substrate for human leukocyte and porcine pancreatic elastase; excitation: 355-380 nm; emission 440-460 nm
Cayman Chemical -Asenapn 10mg
An atypical antipsychotic; binds to dopamine D1-4, α-adrenergic, and histamine receptors (Kis = 0.42-1.45, 0.32-1.26, and 1-6.17 nM, respectively), as well as various 5-HT receptors (Kis = 0.03-3.98 nM); inhibits DOI, apomorphine, or clonidine-induced neuron firing in rat brain (ED50s = 75, 40, and 85 μg/kg, respectively); increases mPFC, NAc, and lateral striatum extracellular dopamine and suppresses the conditioned avoidance response in rats from 0.05-0.2 mg/kg, s.c.; prevents acute and chronic phencyclidine-induced deficits in cued reversal learning in rats at 0.075 mg/kg
Cayman Chemical CystInyl-bIs-glycIn 10mg
A dipeptide intermediate in the synthesis of oxidized glutathione that is composed of two cysteinylglycine peptides linked by a disulfide bond; formed via nonenzymatic oxidation of cysteinylglycine
Cayman Chemical 16-Oxokahweol 10mg
A synthetic diterpene; increases cytosolic GST activity and acid-soluble sulfhydryl levels in mouse liver and small bowel mucosa at 10 µmol once per day for three days
Cayman Chemical NS 8593hydrochlorIde 10mg
An inhibitory gating modifier of SK channels (Kds = 0.42, 0.6, and 0.73 μM for SK1, SK2, and SK3, respectively, in the presence of calcium); decreases the calcium sensitivity of SK channels; selective for SK channels over IK and BK potassium channels at 10 μM; induces relaxation of potassium- or acetylcholine chloride-precontracted isolated tracheal rings from wild-type mice (IC50s = 8.9 and 39.8 μM, respectively) or from mice in an ovalbumin-induced model of allergic asthma (IC50s = 16.4 and 32.2 μM, respectively); inhibits aerosolized acetylcholine chloride-induced increases in respiratory system resistance in mice when administered as an aerosol at 500 μM; decreases the duration of burst-pacing-induced atrial fibrillation in normotensive and spontaneously hypertensive rats at 5 mg/kg
Cayman Chemical 5fluoro PB22 6hdroxquIno 10mg
Differs from 5-fluoro PB-22 by having the ester linkage inserted at the six, rather than eight, position of the quinoline moiety; intended for forensic and research purposes
Cayman Chemical SIsunatovIr 10mg
An RSV fusion inhibitor (IC50 = 0.9 nM); reduces RSV A2 replication in a plaque reduction assay in vitro (EC50 = 1.3 nM); decreases lung viral titers in a mouse model of RSV infection at 1, 10, or 50 mg/kg
Cayman Chemical ChenodeoxycholylcadaverIn 10mg
A polyamine bile amidate; has been used as a standard in the detection of chenodeoxycholyl-cadaverine in mammalian intestinal and fecal samples
Cayman Chemical EG 00229trIfluoROCTAte sa 10mg
An NRP-1 antagonist; inhibits the binding of VEGF-A to porcine aortic endothelial cells expressing NRP-1 but not VEGFR2 (IC50 = 8 µM); reduces VEGF-A-induced migration of HUVECs and enhances the cytotoxicity of paclitaxel or 5-fluorouracil in A549 lung cancer cells; reduces SARS-CoV-2 infectivity in Caco-2 cells at 100 µM
Cayman Chemical ATN161trIfluoroACTAte sal 10mg
An integrin receptor antagonist; binds to αVβ3 and αVβ5 receptors (Kds = 0.69 and 1 µM, respectively) in MDA-MB-231 cells; inhibits the interaction between αVβ5 and human ACE2 or SARS-CoV-2 spike protein in cell-free assays; reduces viral titers in Vero E6 cells infected with SARS-CoV-2 (EC50 = 3.16 µM); inhibits VEGF-induced migration and capillary tube formation of primary human choroidal endothelial cells at 0.1 µM; reduces tumor growth and metastasis in an MDA-MB-231 mouse xenograft model at 1 mg/kg; reduces infarct volume and edema in a mouse model of MCAO-induced ischemic stroke at 1 mg/kg
Cayman Chemical 7 S 10 S-DIHOME 10mg
An antibacterial hydroxy fatty acid; active against various food-borne pathogenic bacteria (MIC50s = 31.3-250 UG/ml), as well as various plant pathogenic bacteria (MIC90s = 125-500 UG/ml, respectively)
Cayman Chemical TubermycIn B 10mg
A bacterial metabolite; active against A. flavus, C. albicans, F. oxysporum, R. solani, and T. rubrum (MICs = 64, 8, 125, 32, and 4 UG/ml, respectively); prevents the development of foliar anthracnose lesions in C. orbiculare-infected cucumber plants
Cayman Chemical N6benzoylCyclIc AMPsodIM 10mg
A cell permeable cAMP analog that selectively activates PKA over Epac1 and 2 (also known as RAPGEF3 and 4); binds the AI and AII subunits of PKA with pKi values of 4.0 and 3.8, respectively, whereas it binds Epac1 with a pKi value of 1.3